Despite their importance in gene expression processes, and in contrast to other classes of RNPs such as ribosomes and spliceosomes, the makeup and transformations of individual messenger ribonucleoproteins (mRNPs) remain a mystery. The NOMIS research project Visualizing the Messenger aims to discern the structure and biochemical nature of mRNPs in the brain throughout the mRNA life cycle.
Recent breakthroughs in ad hoc biochemical approaches pioneered by Elena Conti and her lab have minimized issues with mRNP fragility and variability, allowing for the isolation of endogenous intact mRNPs. Elucidating their structure will provide insights into the mechanisms with which they function in neuronal processes and will facilitate a molecular understanding of how mutations in mRNP components lead to neurological diseases.
Wednesday, October 16, 2024 | 17:00 | Kunsthaus Zurich, Chipperfield Building
